Solid-form design of pharmaceutical products

Integration of active pharmaceutical ingredient solid form selection and particle engineering into drug product design.

This review seeks to offer a broad perspective that encompasses an understanding of the drug product attributes affected by active pharmaceutical ingredient (API) physical properties, their link to solid form selection and the role of particle engineering. While the crucial role of active pharmaceutical ingredient (API) solid form selection is universally acknowledged in the pharmaceutical indu...

Solid Free Form Design for Structural Optimization

Most of the work in the field of topology optimization is concentrated on using sensitivity analysis and optimality criteria methods that need explicit formulation. The design systems are often hard-coded for a specific problem with specialized optimization and FEM routines. This paper presents a work that uses a system approach to solid free form design. It attempts to develop a general topolo...

British Pharmaceutical Products

Bayer's Pharmaceutical Products

Solid forms of pharmaceutical molecules

A drug discovery is characterized by two stages. The first in terms of time is called „lead structure“, followed by a so called „drug candidate“ stage. The lead structure stage involves selecting the optimum molecule of the pharmaceutical, while drug candidate stage means selecting the optimum solid form. Usually, 5 – 10 candidates pass to the drug candidate stage and the result is the selectio...